corticosteroid (corticosteroide)

Contexto del término In this review, we will highlight several principles that have become evident from recent work by us and other investigators. First, (as mentioned above), corticosteroids change the neurophysiology of hippocampal neurons not just in a delayed manner, but also more rapidly, thus encompassing a wide span of time. Second, it is evident that corticosterone acts in concert and interaction with other stress mediators, e.g. noradrenaline. Third, actions of corticosterone strongly depend on the local network properties and cellular context, so that effects observed in a particular hippocampal subfield cannot be simply extrapolated to other limbic areas. And finally, a stress-induced surge in corticosteroid level does not always affect a given cell type (e.g. a CA1 pyramidal neuron) in the same way: The effect strongly depends on the life history of the organism.